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目的探讨窒息新生儿Scr和BUN水平变化及禁食时间对其变化的影响。方法根据病史和临床表现将100例新生儿分为窒息组和对照组。检测窒息组和对照组入院6 h内Scr和血BUN水平,并记录每例患儿24 h尿量。同时检测窒息组患儿禁食4 h、24 h、48 h和开奶前1 h及开奶后48 h Scr和BUN水平。窒息组禁食期间和开奶后48 h内基础治疗及给氧时间、给氧体积分数均相同,均未用对肾功能有影响的药物。结果窒息组与对照组、轻度窒息组与重度窒息组、禁食4 h与禁食24 h和48 h、开奶前1 h与开奶后48 h Scr水平比较,差异均有统计学意义(Pa<0.05)。窒息可引起Scr水平增高,窒息程度越重,Scr水平增高越明显。窒息组与对照组、轻度窒息组与重度窒息组BUN水平比较,差异均无统计学意义(Pa>0.05),且24 h尿量均>1 mL.kg-1.h-1。结论窒息禁食时可引起Scr水平增高,如病情许可,禁食时间不宜过长,并适当静脉补充蛋白质和氨基酸。
Objective To investigate the changes of Scr and BUN levels and the effects of fasting time on neonatal asphyxia neonates. Methods According to the history and clinical manifestations, 100 neonates were divided into asphyxia group and control group. The levels of Scr and blood BUN within 6 h after admission in asphyxia group and control group were measured, and the urine output of 24 h in each group was recorded. At the same time, the levels of Scr and BUN in 4 h, 24 h, 48 h, 1 h before opening milk and 48 h after opening milk were also measured in the asphyxia group. Asphyxia group during fasting and within 48 h after opening milk basic treatment and oxygen time, oxygen volume fraction were the same, were not used on the renal function of the drug. Results There were significant differences in Scr levels between asphyxia group and control group, mild asphyxia group and severe asphyxia group at 4 h of fasting, 24 h and 24 h of fasting, 1 h before opening and 48 h after opening of milk (Pa <0.05). Asphyxia can cause increased Scr levels, asphyxia heavier, the more obvious increase in Scr levels. There were no significant differences in BUN levels between asphyxia group, control group, mild asphyxia group and severe asphyxia group (Pa> 0.05), and urine volume of 24 h was> 1 mL.kg-1.h-1. Conclusion Asphyxial fasting can cause increased Scr levels, such as permission, fasting time should not be too long, and appropriate intravenous supplementation of protein and amino acids.