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目的观察银杏叶片联合人际心理干预治疗冠心病合并抑郁症患者的疗效。方法该研究设计为单中心、随机对照研究,入选220例冠心病合并抑郁症患者,随机分为对照组(人际心理干预)和治疗组(银杏叶片48 mg,tid+人际心理干预),疗程6 mo。分别在治疗前和治疗后3、6 mo评定汉密尔顿抑郁量表24项(HAMD-24)和贝克抑郁量表(BDI-Ⅱ)评分,次要指标观察全因死亡率、因冠心病发作再次入院的情况和不良反应。结果治疗前2组HAMD-24评分和BDI-Ⅱ评分无显著差异(P>0.05);治疗3、6 mo末,2组的HAMD-24评分、BDI-Ⅱ评分均较治疗前显著改善(P<0.01),且治疗组比对照组改善更为显著(P<0.05)。治疗组3 mo时总有效率为37%,6 mo时总有效率为51%,分别高于同时点对照组(21%和29%,P<0.01)。2组在全因死亡率、不良反应和再次住院率上无显著差异(P>0.05)。结论应用银杏叶片联合人际心理干预治疗冠心病合并抑郁症,疗效优于单纯人际心理干预。
Objective To observe the curative effect of ginkgo leaf combined with interpersonal psychological intervention on patients with coronary heart disease and depression. Methods The study was designed as a single-center, randomized, controlled study of 220 patients with coronary heart disease and depression who were randomly divided into control group (interpersonal psychological intervention) and treatment group (Ginkgo biloba 48 mg, tid + interpersonal psychological intervention) for 6 months . The Hamilton Depression Inventory 24 (HAMD-24) and the Beck Depression Inventory (BDI-II) were scored before treatment and 3 and 6 months after treatment respectively. The secondary indexes were all-cause mortality, re-admission due to coronary heart disease The situation and adverse reactions. Results There was no significant difference between HAMD-24 score and BDI-Ⅱ score before treatment (P> 0.05). At the end of 3 and 6 months, HAMD-24 score and BDI-Ⅱ score were significantly improved in both groups <0.01), and the treatment group improved more significantly than the control group (P <0.05). In the treatment group, the total effective rate was 37% at 3 months and 51% at 6 months, which was higher than that of the control group (21% vs 29%, P <0.01). There was no significant difference between the two groups in all-cause mortality, adverse reactions and re-hospitalization rate (P> 0.05). Conclusion The application of Ginkgo biloba leaf combined with interpersonal psychological intervention in the treatment of coronary heart disease complicated with depression is better than pure interpersonal psychological intervention.