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AIM To study the relationship between the lipid peroxide (LPO) and superoxide dismutase (SOD) and thepathogenesis of gastrointestinal cancers.METHODS We investigated the SOD activity and LPO levels in blood and mucosa of patients withesophageal (EC), gastric (GC) and colorectal cancer (CC), gastric ulcer (GU) and compared with normalesophagus (NE), stomach (NS) and colon (NC). respectively, 287 patients who underwent endoscopy werestudied. SOD activity of the tissue and blood was determined using SUN's adrenaline auto oxidation method.LPO levels were determined according to YU's method.RESULTS The SOD activity and LPO level in blood and mucosa are shown in the Table 1 (x±Sx).
Table 1 SOD and LPO in blood and tissues of patients with gastrointestinal cancers
SOD(U／mg protein)
LPO(U／mg)
Groups
n
Tissue
blood
Tissue
Blood
Normal stomach
Gastric ulcer
Gastric cancer
Normal esophagus
Esophageal cancer
Normal colon
Colon cancer
60
42
43
32
52
28
30
1.90±0.18
0.64±0.40a
0.37±0.24a
1.17±0.70
0.39±0.30a
0.81±0.36
0.31±0.17b
33.70±1.73
25.50±0.67b
27.86±1.02b
30.80±3.78
28.23±10.63
20.97±4.77
19.35±7.32
0.01±0.004
0.05±0.010b
0.06±0.021b
0.014±0.005
0.061±0.033b
0.012±0.003
0.069±0.015b
0.83±0.01
0.11±0.02
0.12±0.03
0.08±0.02
0.11±0.02
0.08±0.03
0.11±0.02
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