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将60～80岁具有肾虚衰老症状的健康男性80例,随机分为五子衍宗液组及糖水安慰剂组,采用单盲法,服药5周。结果表明:五子衍宗液可使老年肾虚衰老症状的总积分值下降(P<0.01),红细胞中超氧化物歧化酶(SOD)活力升高(P<0.01),血浆过氧化脂质(LPO)含量下降;血浆睾酮(T)含量上升(P<0.01),雌二醇(E_2)与T比值下降(P<0.01)。而糖水安慰剂组治疗前后均无明显变化。提示减少自由基中毒损伤,增强抗氧化酶活力及调节体内性激素水平,可能是五子衍宗液治疗老年肾虚、延缓衰老的主要作用机制之一。
The 80-80-year-old healthy male with symptoms of kidney aging was randomly divided into Wuzi Yanzong liquid group and sugar water placebo group. The single-blind method was used for 5 weeks. The results showed that: Wuzi Yanzong Liquid can reduce the total value of aging symptoms of aging kidney deficiency (P <0.01), red cell superoxide dismutase (SOD) activity increased (P <0.01), plasma lipid peroxides (LPO) The content decreased; plasma testosterone (T) content increased (P <0.01), estradiol (E_2) and T ratio decreased (P <0.01). There was no significant change in the placebo group before and after treatment. It suggests that reducing free radical poisoning damage, enhancing antioxidant enzyme activity and regulating the level of sex hormones in the body may be one of the main mechanisms for the treatment of aging kidney deficiency and delaying aging.