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Ghrelin是新近发现的一种肠肽类激素,是生长激素促分泌素的内源性配体。Ghrelin能够与其受体结合发挥多种生物学作用,可促进生长激素释放、增加摄食、调节脂肪代谢;此外,还具有抑制炎症因子释放、降低血压、保护血管内皮细胞、扩张冠状动脉、改善心力衰竭症状等多种生物学效应。作为一种小分子多肽,Ghrelin在心血管疾病及其相关疾病中具有潜在临床价值。
Ghrelin is a newly discovered intestinal peptide hormone that is an endogenous ligand for growth hormone secretagogues. Ghrelin can bind with its receptor to play a variety of biological effects, can promote the release of growth hormone, increase food intake, regulate fat metabolism; In addition, it also has the effect of inhibiting the release of inflammatory cytokines, lowering blood pressure, protecting vascular endothelial cells, dilating coronary arteries, improving heart failure Symptoms and other biological effects. As a small molecule peptide, Ghrelin has potential clinical value in cardiovascular diseases and their related diseases.