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据最新的《美国国家科学院学报》报道,Johns Hopkins大学的科学家们发现了一种可以选择性攻击小鼠体内晚期肿瘤的细菌。 晚期肿瘤通常都有因血液循环微弱而缺氧的区域。缺氧使得晚期肿瘤对常规的化学疗法和放射线疗法较有抗性,但对于厌氧生长的细茵而言,却是开放的。 因此,科学家们便想利用一种厌氧菌厌氧的特点,引导它们直接作用于大型肿瘤中已经死亡或快要死亡的细胞团。“我们的想法是用这种细菌从内部攻击肿瘤,而用化学疗法从外剖攻击。“哈佛大学Hughes医学院的肿瘤学教授 Bert Vogelstein博士说。 科学家们系统地筛查了无数细菌种类,以找到可以在缺氧环境下生长同时又对周围肿瘤细胞有破坏作用的细菌。最后,他们将目标锁定在一个孢子繁殖的细菌种类——Clostridium novyi（C.novyi）上。正常情况下,
According to the latest Proceedings of the National Academy of Sciences, scientists at Johns Hopkins University discovered a bacterium that selectively attacks advanced tumors in mice. Advanced tumors usually have weak and hypoxic areas of blood circulation. Hypoxia allows advanced tumors to be more resistant to conventional chemotherapies and radiation therapies, but open to anaerobes that grow anaerobically. Therefore, scientists would like to take advantage of the anaerobic characteristics of anaerobic bacteria, leading them to act directly on large tumor cells that have died or are dying. “Our idea is to use this bacterium to attack the tumor internally and to use chemotherapy to attack it from the exterior,” said Bert Vogelstein, MD, a professor of oncology at Hughes Medical School at Harvard University. Scientists have systematically screened innumerable bacterial species to find bacteria that can grow in anoxic environments with damaging effects on surrounding tumor cells. In the end, they targeted the bacteria that breed spores - Clostridium novyi (C. novyi). Under normal circumstances,