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目的 对呼吸道合胞病毒 (RSV)感染的住院儿童的感染程度与危险因素进行相关分析。方法 (1)选择综合指标严重指数 (SI)对 12 2例确诊为RSV感染的 0～ 1岁的患儿进行RSV感染严重程度的评价 ,SI≥ 3者为重症感染 ;(2 )设预期潜在性疾病、年龄≤ 3个月和早产为RSV重症感染的危险因素 ,根据有无危险因素将 12 2例住院患儿划分为高危组和低危组 ;(3)对感染程度与危险因素进行相关分析。结果 (1)以早产和年龄≤ 3个月作为危险因素 ,高危组 71例 ,SI≥ 3者明显超过低危组 (P <0 .0 5 ) ;(2 )以潜在性疾病和年龄≤ 3个月 ,或以早产和潜在性疾病作为危险因素 ,高危组分别为 6 9例和 17例 ,SI≥ 3者略多于低危组 ,但差异无显著意义 ;(3)多因素Logistic分析显示 ,早产、年龄≤ 3个月与重症感染呈显著正相关 (r=0 .2 487、0 .1945 ,P <0 .0 5、0 .0 0 1) ,潜在性疾病与重症感染无关 (P >0 .0 5 )。 (4)经回归方程计算 ,早产儿感染RSV后 5 0 .7%有可能发生重症感染 ,非早产儿感染后仅 2 .2 %可能发生重症感染 (P =0 .0 12 )。年龄≤ 3月龄、潜在性疾病等因素进入回归方程计算均无显著意义。结论 RSV感染严重程度与早产、年龄≤ 3个月密切相关 ,二者是重症感染的危险因素 ,且早产是重症感染的预示指标 ;而潜在性?
Objective To analyze the correlation between infection and risk factors of hospitalized children with respiratory syncytial virus (RSV) infection. Methods (1) The severity index of RSV infection was evaluated in 12 2 children aged 0-1 years who were diagnosed as RSV infection by selecting the index of comprehensive index (SI), and those with SI≥3 were severe infections. (2) Sexually transmitted diseases, age ≤ 3 months and preterm birth were risk factors for severe RSV infection. According to the presence or absence of risk factors, 122 inpatients were divided into high-risk group and low-risk group. (3) Correlation between infection level and risk factors analysis. Results (1) Preterm and age ≤ 3 months were risk factors in high risk group (71 cases), SI≥3 significantly higher than low risk group (P <0. 05); (2) With underlying disease and age ≤ 3 Months, or premature and potential disease as risk factors, high-risk group were 69 cases and 17 cases, SI ≥ 3 slightly more than the low-risk group, but no significant difference; (3) Multivariate logistic analysis showed , Preterm birth, age≤3 months had a significant positive correlation with severe infection (r = 0.247,0.1945, P <0.05,0.01), and the underlying disease was not associated with severe infection > 0 .0 5). (4) According to the regression equation, 50.7% of preterm infants with RSV infection may develop severe infection, and only 2.2% of premature infants may have severe infection (P = 0.122) after infection. Age ≤ 3 months of age, potential disease and other factors into the regression equation was not significant. Conclusions The severity of RSV infection is closely related to preterm birth and age ≤ 3 months. Both are risk factors for severe infection, and preterm birth is a predictor of severe infection.