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系统性红斑狼疮(systemic lupus erythematosus,SLE)患者的外周血单核细胞制备物中存在低密度粒细胞(low density granulocyte,LDG)。LDG的核为不成熟状态,根据表面标记物CD15、CD14和CD10能区分单核细胞和LDG。LDG与正常密度粒细胞的表面标记物无明显差异,但其表达水平不同。SLE LDG有许多基因组改变,包括拷贝数变化、杂合性损失和微卫星不稳定。LDG分泌高水平促炎因子和I型干扰素,具有促炎性和内皮细胞毒性,阐明LDG的致病性可为自身免疫性疾病和内皮损伤性疾病设计新的治疗策略。
In patients with systemic lupus erythematosus (SLE), low density granulocytes (LDG) are present in peripheral blood mononuclear cell preparations. The nuclei of LDG are immature, and monocytes and LDG can be distinguished based on the surface markers CD15, CD14 and CD10. LDG and normal density granulocyte surface markers no significant difference, but its expression levels are different. SLE LDG has many genomic changes, including changes in copy number, loss of heterozygosity and microsatellite instability. LDG secretes high levels of proinflammatory cytokines and type I interferons with proinflammatory and endothelial cell cytotoxicity and elucidates that the pathogenicity of LDG may lead to the design of novel therapeutic strategies for autoimmune and endothelial injury.