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目的探讨血尿酸浓度升高是否为高血压的独立预测因子。方法对河北省老年病医院心内科2007年9月至2008年2月住院患者临床资料进行回顾性分析,选择根据2005年WHO高血压病诊断标准确诊为高血压病患者128例(1级高血压26例,2级高血压46例,3级高血压56例),年龄65(64.49±11.03)岁,其中男99例、女29例;同期血压正常的连续性入院患者87例作为对照组,年龄62(61.25±10.98)岁,其中男53例、女34例。入院第2天清晨取空腹12h抽取静脉血进行血尿酸、血脂等各种生化检查,详细询问包括吸烟、冠心病、糖尿病等病史。入院期间进行动态血压监测。结果高血压组血尿酸浓度高于对照组[(496.31±42.33)μmol/L对(356.08±50.68)μmol/L,P<0.01],且随着血压的升高血尿酸浓度及高尿酸血症比例也随之增高。但Logistic回归分析显示血尿酸并非高血压病的独立危险因素。结论血尿酸浓度升高可能只是高血压病的一个标志,而非高血压病的独立危险因素。
Objective To investigate whether elevated serum uric acid concentration is an independent predictor of hypertension. Methods The clinical data of inpatients from September 2007 to February 2008 in Department of Cardiology of Geriatric Hospital of Hebei Province were retrospectively analyzed. Among them, 128 cases were diagnosed as Hypertension according to the diagnostic criteria of WHO in 2005 (Grade 1 hypertension 26 cases, grade 2 hypertension in 46 cases, grade 3 hypertension in 56 cases), age 65 (64.49 ± 11.03) years old, including 99 males and 29 females; 87 patients with normotensive continuous admission in the same period were taken as control group, Age 62 (61.25 ± 10.98) years of age, including 53 males and 34 females. On the second day after admission, take fasting 12h and take venous blood for various biochemical tests such as serum uric acid and lipids. Ask in detail about the medical history including smoking, coronary heart disease and diabetes mellitus. Ambulatory blood pressure monitoring during admission. Results The level of serum uric acid in hypertension group was higher than that in control group [(496.31 ± 42.33) μmol / L vs (356.08 ± 50.68) μmol / L, P <0.01] The proportion will also increase. But Logistic regression analysis showed that serum uric acid was not an independent risk factor for hypertension. Conclusion The elevated serum uric acid concentration may be only a marker of hypertension, not an independent risk factor for hypertension.