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目的研究砷暴露地区居民饮用水砷浓度与指甲砷、硒含量及砷暴露人群临床分度之间的关系。方法对内蒙古巴彦淖尔市杭锦后旗和五原县不同水砷浓度暴露的599位居民进行指甲采样和临床砷中毒检查。利用电感耦合等离子质谱仪(ICPMS)测定水砷浓度,中子活化分析法(INAA)测定指甲内砷和硒的含量。结果水砷与指甲砷含量呈正相关(r=0.896,P<0.01),水砷与指甲硒含量呈负相关(r=-0.322,P<0.01),指甲砷与指甲硒含量也呈负相关(r=-0.355,P<0.01),指甲砷与砷暴露人群临床分度呈正相关(r=0.225,P<0.01)。不同浓度砷暴露人群砷中毒临床分度构成不同,差异显著(P<0.01)。结论砷暴露人群指甲砷与指甲硒呈负相关,提示在人体内砷与硒存在着拮抗效应,且指甲砷含量与砷暴露人群临床分度呈一致趋势,指甲砷对地方性砷中毒的诊断具有重要价值。
Objective To study the relationship between drinking water arsenic concentration, nails arsenic and selenium content and clinical index of arsenic exposed people in arsenic exposed areas. Methods Nail samples and clinical arsenic poisoning were examined in 599 residents exposed to different water Arsenic concentrations in Hangjinhou Banner and Wuyuan County in Bayannur City, Inner Mongolia. The concentration of arsenic in water was determined by inductively coupled plasma mass spectrometry (ICPMS), and the content of arsenic and selenium in nails was determined by neutron activation analysis (INAA). Results There was a positive correlation between arsenic and arsenic (r = 0.896, P <0.01), arsenic and nails (r = -0.322, P <0.01), arsenic and nails r = -0.355, P <0.01). There was a positive correlation between nails and arsenic exposure (r = 0.225, P <0.01). The clinical classification of arsenic poisoning in different concentrations of arsenic exposed people was different, the difference was significant (P <0.01). Conclusions Arsenic and arsenic are negatively correlated with nosocomial arsenic exposure, suggesting that there is antagonistic effect of arsenic and selenium on human arsenic exposure. And the arsenic content of nails shows a consistent trend with that of arsenic exposed people. Nail arsenic has the following effects on the diagnosis of endemic arsenism: Important value.