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目的观察阑尾杯状细胞类癌(GCC)的临床病理特征。方法对5例阑尾GCC的组织切片、特殊染色和免疫组化结果进行观察并分析临床资料。结果患者中2例男性,3例女性,平均年龄54.6岁,临床上多表现为急性阑尾炎的症状和体征。巨检:阑尾无明显肿块。镜检:GCC由形态一致的杯状细胞形成巢状结构,呈浸润性生长,5例均侵及阑尾浆膜层,2例侵犯神经。GCC瘤细胞形态上类似于肠腺杯状细胞,无异型性和坏死,缺乏核分裂。瘤细胞AB、PAS、NSE、CgA、Syn、CEA和CK8(+)。随访3例,各为14、156和165个月,均存活,其中2例行右半结肠切除。结论GCC是一种在组织形态和免疫表型上具有外分泌和内分泌肿瘤双重特点的肿瘤,较经典类癌更具侵袭性。患者经阑尾切除+右半结肠切除预后良好。
Objective To observe the clinicopathological features of appendix goblet cell carcinoid (GCC). Methods The tissue sections, special staining and immunohistochemistry results of 5 cases of appendix GCC were observed and analyzed. Results Two patients were male and three were female, with an average age of 54.6 years. Most of the patients showed symptoms and signs of acute appendicitis. Giant check: appendix no significant mass. Microscopic examination: GCC consisted of nests of goblet cells in the same shape and grew infiltratively. All of 5 cases invaded the appendicitis serosa and 2 cases infringed on nerves. GCC tumor cells morphologically similar to enteric goblet cells, no atypia and necrosis, the lack of nuclear fission. Tumor cells AB, PAS, NSE, CgA, Syn, CEA and CK8 (+). Three cases were followed up for 14,156 and 165 months, both of whom survived. Among them, 2 patients underwent right colon resection. Conclusions GCC is a kind of tumor that has both exocrine and endocrine neoplasms in histomorphology and immunophenotype, which is more aggressive than classical carcinoid. Patients with appendectomy + right colon resection a good prognosis.