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目的:观察清淤利胆汤联合西药治疗湿热型妊娠期肝内胆汁淤积症(ICP)临床疗效及对患者转氨酶及胆汁酸水平的影响。方法:将ICP患者82例随机分为2组各41例。对照组给予西医常规治疗,观察组在对照组的基础上给予清淤利胆汤治疗,观察2组疗效及新生儿结局,比较治疗前后中医症状评分、转氨酶(ALT)及胆汁酸(TBA)水平变化。结果:观察组总有效率为95.12%,对照组为75.61%,2组比较,差异有统计学意义(P<0.05)。治疗后2组中医症状皮肤瘙痒、黄疸、心烦、面色萎黄评分均较治疗前下降(P<0.05),且观察组各症状评分下降较对照组更显著(P<0.05)。疗后2组TBA、ALT值均较治疗前下降(P<0.05),且观察组上述指标改善较对照组更显著(P<0.05)。结论:清淤利胆汤联合西药治疗湿热型ICP,能够降低患者TBA、ALT水平,改善新生儿结局。
Objective: To observe the clinical efficacy of Qingtang Lidan Decoction combined with western medicine in the treatment of damp-heat intrahepatic cholestasis of pregnancy (ICP) and its effect on the level of transaminase and bile acid in patients. Methods: 82 patients with ICP were randomly divided into two groups of 41 cases. The patients in the control group were given routine treatment of Western medicine. The observation group was given Qingre Ligang Decoction on the basis of the control group. The curative effect and neonatal outcome were observed. The TCM symptom scores, ALT and TBA levels were compared before and after treatment. Variety. Results: The total effective rate was 95.12% in the observation group and 75.61% in the control group. There was significant difference between the two groups (P <0.05). After treatment, the symptom of pruritus, jaundice, upset and pale complexion in two groups of TCM symptoms were lower than those before treatment (P <0.05), and the score of each symptom in the observation group was more significant than that in the control group (P <0.05). After treatment, TBA and ALT in both groups were significantly lower than those before treatment (P <0.05), and the improvement of the above indexes in the observation group was more significant than that in the control group (P <0.05). Conclusion: Qingrejiedu Decoction combined with Western medicine in the treatment of damp-heat ICP can reduce the level of TBA and ALT and improve the outcome of neonates.