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目的探讨支气管肺泡灌洗(BAL)对难治性肺炎(RP)患儿支气管肺泡灌洗液(BALF)中IL-25水平的影响。方法回顾性分析台州恩泽医疗中心2013年8月-2015年8月住院RP患儿58例,比较BAL治疗前、治疗第1周、第2周、第4周BALF中IL-25水平变化,并与咳嗽评分、治疗时间和治疗效果进行相关性分析。结果 BAL治疗前、治疗第1周、第2周和第4周BALF中IL-25浓度分别为(11.03±2.03)pg/ml、(9.71±1.69)pg/ml、(7.14±1.43)pg/ml、(4.48±1.41)pg/ml,差异有统计学意义(F=169.27,P<0.01);BALF中IL-25浓度与不同治疗时间咳嗽评分呈正相关(r值在0.85~0.91,P<0.01);BALF中IL-25浓度在RP痊愈、显效、有效、无效时分别为(2.33±0.82)pg/ml、(4.34±0.84)pg/ml、(5.73±1.56)pg/ml、(6.50±0.71)pg/ml,差异有统计学意义(F=17.21,P<0.01);IL-25水平与RP疗效呈正显著相关(r=0.83,P<0.01)。结论 BAL能显著提高RP疗效,BALF中IL-25水平对RP疗效判断具有重要意义。
Objective To investigate the effect of bronchoalveolar lavage (BAL) on the level of IL-25 in bronchoalveolar lavage fluid (BALF) in children with refractory pneumonia (RP). Methods A retrospective analysis of Taizhou Enze Medical Center from August 2013 to August 2015 in 58 children with hospitalized children with RP was performed to compare the change of IL-25 level in BALF before and after the first week, the second week and the fourth week of treatment Correlation analysis with cough score, treatment time and treatment effect. Results Before BAL treatment, the concentrations of IL-25 in BALF were (11.03 ± 2.03) pg / ml, (9.71 ± 1.69) pg / ml and (7.14 ± 1.43) pg / ml (4.48 ± 1.41) pg / ml, the difference was statistically significant (F = 169.27, P <0.01). The concentration of IL-25 in BALF was positively correlated with the cough score at different treatment time (r = 0.85-0.91, P < 0.01). The concentrations of IL-25 in BALF were (2.33 ± 0.82) pg / ml, (4.34 ± 0.84) pg / ± 0.71) pg / ml, the difference was statistically significant (F = 17.21, P <0.01). The level of IL-25 was positively correlated with the effect of RP (r = 0.83, P <0.01). Conclusion BAL can significantly improve the therapeutic effect of RP, and the level of IL-25 in BALF is of great significance for the judgment of RP.