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目的观察参苓白术散在临床防治直肠放射性损伤方面的效果。方法将96例妇科肿瘤(子宫颈癌78例、子宫内膜癌18例)随机分成两组,一组为中药加放疗组(观察组,49例),另一组为单纯放疗组(对照组,47例)。两组外照射1.8～2.0Gy/次,5次/周,5～6周,总剂量48～50Gy。后装治疗宫颈癌总剂量42～49Gy,6～7周完成;子宫内膜癌总剂量10～15Gy,1～2周完成。观察组从放疗始第1天至放疗结束服用参苓白术散加减,共服用35～38剂。比较观察两组直肠放射性损伤发生情况。结果放疗1年后行纤维结肠镜检查结果显示,观察组共发生15例,其中Ⅰ度为10例,Ⅱ度为3例,Ⅲ度为2例;对照组共发生47例,其中Ⅰ度为24例,Ⅱ度为14例,Ⅲ度为9例。两组比较差异有统计学意义(P<0.01)。结论中药参苓白术散有防治直肠放射性损伤的功效。
Objective To observe the effect of Shenling Baizhu Powder in the prevention and treatment of rectal radiation injury. Methods Ninety-six cases of gynecological tumor (78 cases of cervical cancer and 18 cases of endometrial cancer) were randomly divided into two groups. One group was treated with traditional Chinese medicine plus radiotherapy (observation group, 49 cases), the other was radiotherapy alone group (control group , 47 cases). Two groups of external irradiation 1.8 ~ 2.0Gy / time, 5 times / week, 5 ~ 6 weeks, the total dose of 48 ~ 50Gy. After the treatment of cervical cancer total dose of 42 ~ 49Gy, 6 to 7 weeks to complete; the total dose of endometrial cancer 10 ~ 15Gy, 1 to 2 weeks to complete. Observation group from the first day of radiotherapy to the end of radiotherapy taking Shenling Baizhu addition and subtraction, taking a total of 35 to 38 doses. The incidence of rectal radiation injury in both groups was observed. Results One year after radiotherapy, the results of colonoscopy showed that there were 15 cases in the observation group, of which 10 cases were grade I, 3 cases were grade II and 2 cases were grade III. There were 47 cases in control group, of which grade I was 24 cases, Ⅱ degree 14 cases, Ⅲ degree 9 cases. The difference between the two groups was statistically significant (P <0.01). Conclusion Shenling Baizhu Powder has the efficacy of preventing and treating rectal radiation injury.