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目的:检测血清微量元素(Fe、Mg、Cu、Zn)在口腔黏膜下纤维化(oral submucous fibrosis,OSF)中的表达,并分析年龄因素对血清微量元素的影响。方法:选取73例临床及病理诊断为OSF中期的门诊患者,检测其血清微量元素Fe、Mg、Cu、Zn含量,并按20~30岁、30~40岁、>40岁年龄组分组比较年龄因素对患者血清微量元素的影响,选取20例健康志愿者为对照组。结果:OSF患者血清Fe含量明显高于对照组(P<0.05),而Mg、Cu、Zn含量与对照组差异无统计学意义(P>0.05);OSF各年龄组比较,血清Fe、Mg、Cu、Zn含量均无明显差异(P>0.05),各年龄组微量元素异常率比较,差异也无统计学意义(P>0.05)。结论:OSF患者血清Fe含量偏高,提示临床治疗OSF的同时,需密切关注血清Fe浓度变化情况,并结合血液流变学及贫血形态学检测结果,为寻找更加合理的治疗方案提供参考。
Objective: To detect the expression of serum trace elements (Fe, Mg, Cu, Zn) in oral submucous fibrosis (OSF) and to analyze the effect of age on serum trace elements. Methods: Seventy-three outpatients with clinically and pathologically diagnosed mid-OSF were enrolled in this study. The levels of serum trace elements Fe, Mg, Cu and Zn were measured. The age groups of 20-30 years old, 30-40 years old and> 40 years old were compared. Factors on the serum of trace elements, select 20 healthy volunteers as the control group. Results: The content of serum Fe in OSF patients was significantly higher than that in the control group (P <0.05), while the contents of Mg, Cu and Zn were not significantly different from those in the control group (P> 0.05) There was no significant difference in Cu and Zn contents (P> 0.05). There was no significant difference in the abnormal rates of trace elements in all age groups (P> 0.05). Conclusion: The high serum Fe content in patients with OSF suggests that the treatment of OSF should pay close attention to the changes of serum Fe concentration. Combined with the results of hemorheology and anemia morphology test, it provides a reference for finding a more rational treatment plan.