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目的 :研究复肾丸对早期肾小球硬化的抑制作用。方法 :选用 Spragoe- Dawleg系雄性大白鼠 ,采用单肾切除配合注射阿霉素的方法制作肾小球硬化的动物模型 ,按每公斤体重 1.5g生药的剂量灌服复肾丸溶液 ,连续用药 4周后 ,采血作肾功能、血脂检查 ,留取尿标本作 2 4小时尿蛋白含量检查 ,至第 5周处死 ,取肾标本做病理组织学检查。结果 :复肾丸有明显的消蛋白、改善肾功能、降血脂的效果 ,病理组织学研究的结果亦显示 ,复肾丸有抑制肾小球系膜组织增生的作用。结论 :复肾丸有抑制肾小球硬化 ,改善肾功能的作用
Objective: To study the inhibitory effect of Fu Shen Wan on early glomerular sclerosis. METHODS: Spragoe-Dawleg male rats were selected and a glomerulosclerosis animal model was made by single nephrectomy combined with adriamycin injection. Fu Shen Pill solution was fed orally at a dose of 1.5 g crude drug per kilogram of body weight for 4 consecutive days. After the week, blood was taken for renal function and blood lipid examination. Urinary specimens were taken for 24-hour urinary protein examination and sacrificed at the 5th week. Kidney specimens were taken for histopathological examination. Results: Fushen Pill had obvious effect on protein elimination, renal function improvement, and blood lipid lowering. The results of histopathological study also showed that Fushen Pill could inhibit the proliferation of glomerular mesangial tissue. Conclusion : Fushen pill can inhibit glomerulosclerosis and improve renal function