论文部分内容阅读
目的研究早期肠内营养(EN)对休克患者内毒素及肿瘤坏死因子-α(TNF-α)的作用及全身炎性反应综合征(SIRS)的影响。方法休克67例随机分为早期EN组和肠外营养(TPN)组,检测两组患者肠内营养治疗前、治疗后1、3、5 d血浆中内毒素与TNF-α水平;统计两组SIRS的持续时间与多器官功能障碍(MODS)的发生率。结果早期EN组患者5 d后血浆内毒素与TNF-α明显低于TPN组(P<0.01),SIRS的持续时间与MODS的发病率均低于TPN组(P<0.05)。结论早期肠内营养可显著降低休克后患者血浆内毒素及TNF-α水平,缩短了SIRS的持续时间,降低了MODS的发生率。
Objective To study the effect of early enteral nutrition (EN) on endotoxin, tumor necrosis factor-α (TNF-α) and systemic inflammatory response syndrome (SIRS) in patients with shock. Methods 67 cases of shock were randomly divided into early EN group and parenteral nutrition group (TPN). The levels of endotoxin and TNF-α in plasma before and after enteral nutrition treatment were measured in both groups. The duration of SIRS and the incidence of multiple organ dysfunction (MODS). Results The levels of plasma endotoxin and TNF-α in patients with early EN were significantly lower than those in TPN after 5 days (P <0.01). The duration of SIRS and the incidence of MODS were lower than those of TPN (P <0.05). Conclusions Early enteral nutrition can significantly reduce plasma endotoxin and TNF-α levels after shock, shorten the duration of SIRS and reduce the incidence of MODS.