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目的分析血小板计数(PLT)、纤维蛋白原(FIB)以及PSA相关检测(t-PSA、f-PSA、f/t-PSA)在诊断前列腺癌中的意义。方法采集研究对象的外周静脉血,分别检测PLT、FIB、t-PSA、f-PSA,并对结果进行统计分析。结果前列腺癌组的PLT、FIB、t-PSA、f-PSA显著高于对照组和良性前列腺增生组,差异有统计学意义(P<0.05);而前列腺癌组与良性前列腺增生组f/t-PSA差异无统计学意义(P>0.05);良性前列腺增生组的f/t-PSA显著低于对照组,差异有统计学意义(P<0.05),良性前列腺增生组的PLT、FIB、t-PSA、f-PSA与对照组差异无统计学意义(P>0.05)。PLT、FIB、f/t-PSA的ROC曲线下面积(AUC)分别为0.648、0.656、0.744,约登指数分别为0.287、0.361、0.528;f/t-PSA分别联合PLT、FIB以及3种联合的AUC分别为0.807、0.782、0.828,约登指数分别为0.547、0.539、0.585。结论单独检测PLT、FIB、f/t-PSA对前列腺癌具有一定的诊断意义,3种联合检测可以提高诊断效能。
Objective To analyze the significance of platelet count (PLT), fibrinogen (FIB) and PSA-related tests (t-PSA, f-PSA, f / t-PSA) in the diagnosis of prostate cancer. Methods Peripheral venous blood was collected from patients and PLT, FIB, t-PSA and f-PSA were tested respectively. The results were statistically analyzed. Results The levels of PLT, FIB, t-PSA and f-PSA in prostate cancer group were significantly higher than those in control group and benign prostatic hyperplasia group (P <0.05), while those in benign prostatic hyperplasia group and prostate cancer group were f / t (P> 0.05). The f / t-PSA in benign prostatic hyperplasia group was significantly lower than that in control group (P <0.05). The PLT, FIB, t -PSA, f-PSA and the control group showed no significant difference (P> 0.05). The area under the ROC curve (AUC) of PLT, FIB and f / t-PSA were 0.648,0.656 and 0.744, respectively, and the Youden index were 0.287,0.361,0.528 respectively; f / t- The AUC were 0.807,0.782,0.828, Youden index were 0.547,0.539,0.585. Conclusion The detection of PLT, FIB and f / t-PSA alone has certain diagnostic value for prostate cancer, and the three combined tests can improve the diagnostic efficacy.