论文部分内容阅读
安搏律定(Aprindine Fiboran)又名茚满丙二胺,是具有局麻作用的广谱抗心律失常药。在国外,自1973年报道以来,已广泛应用于临床。现在国内已研制成功,并试用于临床,疗效较好,但也有一定的副作用,现介绍如下: 一、理化性状盐酸安搏律定为白色或类白色粉末,无臭,味苦,有麻痹感。熔点126.5～130℃,极易溶于水,易溶于乙醇、氯仿,微溶于苯。二、电生理学微电极技术研究表明,安搏律定有膜稳定作用,弗唐克(Verdonck)等认为安搏律定的“膜稳定作用”可能是由于膜对Na+通透性降低,而不是对K+通透性增加。
Aprindine Fiboran, also known as indane propylenediamine, is a broad-spectrum anti-arrhythmic drug with local anesthetic activity. Abroad, since the report in 1973, has been widely used in clinical. Now the domestic has been successfully developed and tried in the clinical efficacy is better, but there are also some side effects, are described below: First, the physical and chemical properties Anbo law set as white or off-white powder, odorless, bitter, with paralysis . Melting point 126.5 ~ 130 ℃, easily soluble in water, soluble in ethanol, chloroform, slightly soluble in benzene. Second, the electrophysiological study of microelectrode technology, Anbo law will have a membrane-stabilizing effect, Verdonck and other think of ambroxomidine “membrane stability” may be due to membrane Na + permeability decreased, Instead of an increase in K + permeability.