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最近有他汀随机临床试验分析报告显示,他汀治疗者糖尿病发病率较高。据对13项空白随机试验荟萃分析表明,他汀治疗者显示9%(95%CI:12~17)糖尿病高风险比,另外的5个二级预防试验强化与次强化他汀治疗比较,报告强化者12%(4%~22%)较高的糖尿病风险,一种可能解释是这种偏差是由于存活时间不同,当处于糖尿病高风险患者在他汀治疗下存活期较长。为此,本文对取自500位英国全科医师2000年1月至2010年12月285860例50~84岁男女患者的电子病历进行了分
A recent randomized clinical trial of statin reports showed that statin therapy was associated with a higher prevalence of diabetes. A meta-analysis of 13 randomized trials showed that statin-treated patients showed a high risk of diabetes mellitus of 9% (95% CI: 12-17) and an additional five secondary prevention trials of intensive and statin treatment compared with those reporting fortifier One possible explanation for this is the 12% (4% -22%) higher risk of diabetes, which is due to the different duration of survival and longer duration of statin treatment in patients at high risk of diabetes. To this end, this article from the British general practitioners in 500 from January 2000 to December 2010 285860 male and female patients aged 50 to 84 were divided into electronic medical records