论文部分内容阅读
ARDS 是一严重威胁生命的肺疾患,由于多器官功能衰竭致使机体进行性恶化,死亡率高达50～75%。肺泡壁的通透性改变早于形态学改变,因而寻求早期诊断的指标有重要意义。本文受试者包括13例心源性间质性肺水肿(CIPO)病人(不吸烟),7例ARDS病人,(其中2例吸烟),并以35例正常人(年龄18～50岁,其中13例吸烟)作对照.采用雾化吸入~(99m)Tc-DTPA(2-乙烯-3-胺-5-醋酸盐,分子量492dal。)的方法检测肺清除率,作为肺上皮通透性(PAEP)的指标。~(99m)Tc-DTPA溶于3ml 生理盐水,浓度为6mCi·ml~(-1),雾化后粒子平均直径0.8μm,3次缓慢的潮式呼吸之后,用鼻夹阻
ARDS is a serious life-threatening lung disease that causes progressive deterioration of the body due to multiple organ failure, with a mortality rate of 50-75%. Alveolar wall permeability changes earlier than the morphological changes, and thus seek early diagnosis of the index is of great significance. The subjects included 13 patients with cardiogenic interstitial pulmonary edema (CIPO) (nonsmokers), 7 ARDS patients (2 of whom were smokers) and 35 healthy individuals (aged 18-50 years 13 cases of smoking) as control.Determination of pulmonary clearance was measured by nebulization ~ (99m) Tc-DTPA (2-vinyl-3-amine-5-acetate, molecular weight 492dal.) As lung epithelial permeability (PAEP) indicator. ~ (99m) Tc-DTPA was dissolved in 3ml normal saline at a concentration of 6mCi · ml -1, the mean diameter of the particles after aerosolization was 0.8μm. After 3 times of slow tidal breathing,