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Ⅱ型糖尿病(DM)的预后主要取决于微血管和大血管病变的存在。但是有许多变量存在于病人发生这些并发症的倾向中。虽然血糖控制不良及病程可以预测微血管病变,但它们对大血管病变的预测作用尚不清楚。在Ⅱ型DM中,许多代谢综合征(高血糖、肥胖、高血压、高胰岛素血症、脂代谢紊乱及微白蛋白尿)与源于心血管疾病的不良预后相关。然而,仅约60％的Ⅱ型DM有这些代谢综合征的表现。余下病人中,约10％有GAD抗体和表现为成人晚发自身免疫性糖尿病(LADA)。遗传异质性可能更加掩盖这一表现。
The prognosis of type 2 diabetes mellitus (DM) depends mainly on the presence of microvascular and macrovascular disease. However, many variables exist in the patient’s tendency to develop these complications. Although poor glycemic control and course of disease predict microangiopathy, their role in predicting macroangiopathy is unclear. In type II DM, many metabolic syndromes (hyperglycemia, obesity, hypertension, hyperinsulinemia, dyslipidemia and microalbuminuria) are associated with poor prognosis due to cardiovascular disease. However, only about 60% of Type II DM have these metabolic syndrome manifestations. Of the remaining patients, about 10% have GAD antibodies and present with adult late-onset autoimmune diabetes (LADA). Genetic heterogeneity may be more covered up this performance.