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目的探讨蚓激酶对缺血性脑卒中患者颈动脉粥样硬化的干预作用。方法经超声确诊的颈动脉粥样硬化斑块的缺血性脑卒中患者应用蚓激酶治疗,观察治疗前后血清纤维蛋白原水平、NIHSS评分、颈动脉内膜中层厚度、颈动脉内径及斑块数量、体积等变化情况。结果治疗前后血清纤维蛋白原水平、NIHSS评分、斑块数量、宽径及体积相比有统计学意义。结论持续蚓激酶降纤能延缓、逆转颈动脉粥样硬化,并对缺血性脑卒中患者的二级预防起一定作用。
Objective To investigate the effect of lumbrokinase on carotid atherosclerosis in patients with ischemic stroke. Methods The patients with ischemic stroke diagnosed by ultrasound were treated with lumbrokinase. The serum fibrinogen level, NIHSS score, carotid intima-media thickness, carotid artery internal diameter and plaque volume were observed before and after treatment , Volume and other changes. Results Before and after treatment, serum fibrinogen level, NIHSS score, plaque number, width and volume were statistically significant. Conclusions Sustained PPD can delay and reverse carotid atherosclerosis and play a role in secondary prevention of patients with ischemic stroke.