瘦素与2型糖尿病及炎症

• 作 者: 潘宇 肖常青
• 机 构: 广西医科大学第一附属医院代谢糖尿病中心,广西医科大学第一附属医院代谢糖尿病中心 南宁530021,南宁530021
• 出 处: 医学综述
• 发表日期: 2006年14期
• 关键词: 瘦素 胰岛素抵抗 2型糖尿病 炎症

瘦素(leptin)是脂肪细胞合成并分泌的细胞因子样激素,具有内分泌和细胞因子的双重特征,因此瘦素是联系神经内分泌系统和免疫系统的重要纽带。本文主要阐述瘦素在调节胰岛素分泌、调节脂肪与能量平衡的作用及在免疫方面的潜在机制;瘦素引起胰岛素抵抗和2型糖尿病的可能机制以及瘦素与炎症和感染的关系。对瘦素的进一步研究将为认识2型糖尿病和炎症以及二者之间发病机制的关系提供一个新的线索。

Leptin, a cytokine-like hormone synthesized and secreted by adipocytes, has the dual characteristics of endocrine and cytokine. Leptin is therefore an important link between the neuroendocrine system and the immune system. This article mainly expounds the role of leptin in the regulation of insulin secretion, regulation of fat and energy balance and its potential mechanism in immunology; the possible mechanism of leptin-induced insulin resistance and type 2 diabetes; and the relationship between leptin and inflammation and infection. Further research on leptin will provide new clues for understanding the relationship between type 2 diabetes and inflammation and the pathogenesis of the disease.