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目的:探讨纳络酮治疗新生儿缺氧缺血性脑病(HIE)的体会。方法:收集126例中重度HIE将其分为治疗组69例,对照组57例,2组均采用同样严格的支持疗法和对症处理,在此基础上治疗组给予纳络酮首次0.4 mg加入10%的葡萄糖30 mL内,持续静脉泵控,(0.01 mg/kg～0.03 mg/kg,每8小时1次)。结果:治疗组总有效率91.5%,对照组总有效率73.7%,P<0.01。2组预后比较:治疗组预后不良5例,对照组预后不良13例,治疗组预后优于对照组。结论:纳络酮治疗HIE可使症状消失时间缩短,减轻中重度HIE的并发症,使死亡率明显降低,减少后遗症,改善预后作用取得了满意的效果。纳洛酮治疗中、重度新生儿缺氧缺血性脑病疗效显著。
Objective: To explore the experience of naloxone in treating neonatal hypoxic-ischemic encephalopathy (HIE). Methods: 126 cases of moderate and severe HIE were divided into treatment group 69 cases, control group 57 cases, 2 groups were treated with the same strict support and symptomatic treatment, on the basis of the treatment group was given naloxone 0.4 mg for the first time 10 % Glucose 30 mL, continuous intravenous pump control, (0.01 mg / kg ~ 0.03 mg / kg every 8 hours). Results: The total effective rate was 91.5% in the treatment group and 73.7% in the control group. P <0.01.2: The prognosis was poor in 5 cases in the treatment group and 13 cases in the control group. The prognosis of the treatment group was better than that in the control group. Conclusion: Naloxone treatment of HIE can shorten the disappearance of symptoms, reduce the complications of moderate and severe HIE, the mortality was significantly reduced, reduce the sequelae, improve the prognosis and achieved satisfactory results. Naloxone treatment, severe neonatal hypoxic-ischemic encephalopathy significant effect.