【摘 要】
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Dear editor,rnSodium glucose co-transporter 2 inhibitors (SGLT2I) reduce the majority of reabsorption of glucose in the proximal tubules, which reduces blood glucose levels by allowing excretion of excess glucose in the urine.[1] By inhibiting glucose rea
【机 构】
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NorthShore University Health System,Manhasset,NY 11030,USA
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Dear editor,rnSodium glucose co-transporter 2 inhibitors (SGLT2I) reduce the majority of reabsorption of glucose in the proximal tubules, which reduces blood glucose levels by allowing excretion of excess glucose in the urine.[1] By inhibiting glucose reabsorption, they increase the osmotic pressure of urine resulting in diuresis which can cause a reduction of blood pressure.[2] Fortunately, as these drugs are not directly implicated in altering glucose metabolism or causing insulin secretion, SGLT2I monotherapy does not result in severe hypoglycemia.
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