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目的 :研究大剂量米非司酮口服对子宫肌瘤雌、孕激素受体的影响。方法 :对 18例临床诊断为子宫肌瘤、有手术指征的患者口服大剂量米非司酮 10 0mg/d ,共 5天 ,第 6天手术。选择临床情况相似的子宫肌瘤患者 18例作为对照组。用雌激素受体(ER)、孕激素受体 (PR)单克隆抗体免疫组织化学法检测子宫肌瘤中ER、PR水平。结果 :服药组子宫肌瘤中ER、PR明显低于对照组P <0 .0 5 )。结论 :米非司酮可明显降低子宫肌瘤组织中ER、PR水平。
Objective: To study the effect of high dose mifepristone on estrogen and progesterone receptors in uterine fibroids. Methods: 18 cases of uterine fibroids clinically diagnosed, patients with indications of surgery oral administration of high dose mifepristone 10mg / d, a total of 5 days, the first 6 days of surgery. 18 cases of uterine fibroids with similar clinical conditions were selected as the control group. Estrogen receptor (ER), progesterone receptor (PR) monoclonal antibody immunohistochemical detection of uterine fibroids ER, PR levels. Results: The ER and PR in the uterine fibroids in the medication group were significantly lower than those in the control group (P <0.05). Conclusion: Mifepristone can significantly reduce the level of ER and PR in uterine fibroids.