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小鼠在腹腔注射(D_0)约氏鼠疟原虫前15天(D_(-15))肌注或灌胃咯萘啶100mg/kg,可使大部分小鼠不出现原虫血症。D_(-10)肌注或灌胃10mg/kg,D_(-5)肌注5mg/kg或D_(-4)灌胃5mg/kg亦有抑制原虫血症的作用。因该株原虫对氯喹具固有的抗药性,故即使在D_(-3)肌注或灌胃400mg/kg氯喹(>(2/3)LD_(50))亦不能保护小鼠不受感染。 应用伯氏鼠疟原虫的实验证明:咯萘啶杀裂殖体的持效作用明显比氯喹的为长。咯萘啶剂量为10mg/kg(ED_(50)的1.47倍,或LD_(50)的0.7％)时,D_(-6)灌胃一剂即能抑制原虫血症的出现,但相应剂量的氯喹67mg/kg(ED_(50)的1.47倍,或LD_(50)的10％),仅于D_(-2)给药有微效。
Mice were intraperitoneally injected (D_0) about 15 days before the mouse Plasmodium falciparum (D _ (- 15) intramuscularly or intraperitoneal injection of pyronaridine 100mg / kg, most of the mice will not be parasitemia. D _ (- 10) intramuscular or intragastric administration of 10mg / kg, D _ (- 5) intramuscular injection of 5mg / kg or D _ (- 4) gavage 5mg / kg also inhibited the role of parasitemia. Because of the inherent drug resistance of chloroatrine to this strain of protozoa, mice were not protected from infection even with D_ (- 3) intramuscular or intragastric administration of 400 mg / kg chloroquine (> (2/3) LD50). Experiments using P. berberis parasite proved that pyronaridine hit schizonts significantly longer than chloroquine. When the dose of pyronaridine was 10 mg / kg (1.47 times that of ED 50 or 0.7% of LD 50), the dose of D 6 could inhibit the incidence of protozoa, Chloroquine 67 mg / kg (1.47 times ED_ (50), or 10% of LD_ (50)) only had suboptimal effects on D_ (- 2) administration.