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目的总结和分析在云南省边远的农村地区,对孕妇实施高效反转录病毒治疗(HAART)以预防艾滋病病毒(HIV)母婴传播(PMTCT)的有效性和可行性。方法梳理和定量分析2005-2012年,云南省与美国艾伦戴蒙德艾滋病研究中心开展的预防艾滋病母婴传播项目的效果。结果在1 861名HIV阳性孕妇中,1 353名孕妇(72.7%)采用了HAART阻断方案。在1 584名有HIV检测结果的婴儿中,阳性25人,阳性率为1.58%;其中1 168名采用HAART妇女所生的婴儿中,仅有9人阳性,阳性率为0.8%;在孕28周前开始HAART的妇女所生婴儿中,HIV阳性率为0.2%(2/899)。结论 HAART对于阻断HIV母婴传播效果非常显著,如果在孕28周前开始HAART,婴儿HIV感染率已经非常接近“零感染”的目标,可以推广和实施。
Objective To summarize and analyze the effectiveness and feasibility of implementing highly effective retrovirus treatment (HAART) in pregnant women in remote rural areas of Yunnan Province to prevent mother-to-child transmission of HIV (PMTCT). Methods The results of combating and quantitative analysis of mother-to-child transmission of HIV / AIDS prevention activities in Yunnan Province and the United States Allen Diamond AIDS Research Center from 2005 to 2012 were analyzed and quantitatively analyzed. Results Among 1 861 HIV-positive pregnant women, 1 353 pregnant women (72.7%) adopted the HAART blocking program. Among 1 584 infants with HIV test results, 25 were positive, with a positive rate of 1.58%. Of the 1 168 infants born to HAART women, only 9 were positive and the positive rate was 0.8%. At 28 Among infants born to women who started HAART weeks ago, the HIV positive rate was 0.2% (2/899). Conclusions HAART is very effective in blocking mother-to-child transmission of HIV. If HAART is started 28 weeks before pregnancy, the HIV infection rate in infants is already very close to the goal of “zero infection” and can be promoted and implemented.