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目的对88例自身免疫性甲状腺疾病(AITD)患者进行血清中促甲状腺激素受体抗体(TRAb)、甲状腺过氧化物酶抗体(TPOAb)检测,分析与讨论TRAb、TPOAb在甲状腺疾病中的应用。方法将88例自身免疫性甲状腺病患者分成3组:即甲状腺功能亢进组(甲亢组)、甲状腺功能减退组(甲减组)和甲状腺功能正常组,用电化学发光法检测各组患者血清中TRAb、TPOAb含量,并观察各组中TRAb和TPOAb的变化。结果 TRAb在甲亢组中的阳性率为90.0%,在甲减组阳性率为46.7%,在正常组阳性率为32.1%,TPOAb在甲亢组中的阳性率为66.7%,在甲减组的阳性率为66.7%,在正常组阳性率为53.6%。结论 AITD患者血清中TRAb在甲亢的诊断中有重要的意义。血清中TPOAb阳性不能反映甲状腺功能状态,但AITD患者血清中TPOAb的水平较高,甲减的发生几率增大。
Objective To detect TRAb and TPOAb in 88 patients with autoimmune thyroid disease (AITD), and to analyze and discuss the application of TRAb and TPOAb in thyroid diseases. Methods 88 patients with autoimmune thyroid disease were divided into 3 groups: hyperthyroidism group (hyperthyroidism group), hypothyroidism group (hypothyroidism group) and thyroid function group, the use of electrochemiluminescence assay in each group of patients with serum TRAb, TPOAb content, and observe the change of TRAb and TPOAb in each group. Results The positive rate of TRAb in hyperthyroidism was 90.0%, the positive rate in hypothyroidism was 46.7%, the positive rate in normal group was 32.1%, and the positive rate of TPOAb in hyperthyroidism was 66.7% The rate was 66.7% in the normal group was 53.6%. Conclusion TRAb in serum of patients with AITD is of great significance in the diagnosis of hyperthyroidism. Serum TPOAb positive can not reflect thyroid function status, but AITD serum TPOAb levels are higher, the incidence of hypothyroidism increased.