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目的:研究银杏叶提取物对肾性高血压大鼠(RHR)的降压作用以及血清一氧化氮(NO)的影响,同时观察RHR心、脑、肾组织中丙二醛(MDA),超氧化物歧化酶(SOD)活性的变化。方法:采用两肾一夹法(2K1C)复制肾性高血压大鼠(RHR)模型,将造模成功的大鼠按照血压高低随机分为5组:空白对照组、银杏叶提取物高、中、低剂量组、阳性药卡托普利组,每组8只。在给药前和给药后2,4,6,8周测量大鼠的收缩压(SBP)和舒张压(DBP),在给药后8周,测量大鼠血清NO的含量,测心、脑、肾组织中MDA,SOD的变化。结果:给药8周后,银杏叶提取物明显降低RHR的血压,其中高剂量组的降压幅度与卡托普利组比较没有显著性差异;银杏叶提取物高剂量组和卡托普利组可以提高大鼠血清NO含量,提高心、脑、肾组织中SOD水平,降低MDA含量。结论:银杏叶提取物的降压作用可能与提高舒血管物质NO含量有关,并可能通过抗氧化起到保护靶器官的作用。
Objective: To study the antihypertensive effect of Ginkgo biloba extract on renal hypertensive rats (RHR) and the effect of serum nitric oxide (NO), and to observe malondialdehyde (MDA) in the heart, brain and kidney of RHR. Changes in the activity of oxide dismutase (SOD). METHODS: Renal hypertensive rats (RHR) model was established by two-kidney, one-clip method (2K1C). Rats with successful modeling were randomly divided into five groups according to the blood pressure level: blank control group, Ginkgo biloba extract high and middle , low-dose group, positive drug captopril group, 8 in each group. The systolic blood pressure (SBP) and diastolic blood pressure (DBP) of the rats were measured before and at 2, 4, 6, and 8 weeks after the administration. The serum NO levels were measured at 8 weeks after administration. Changes of MDA, SOD in brain and kidney tissues. RESULTS: After 8 weeks of administration, Ginkgo biloba extract significantly reduced blood pressure in RHR, and the high-dose group had no significant difference in blood pressure lowering rate compared with captopril; Ginkgo biloba extract high-dose group and captopril The group can increase serum NO levels, increase SOD levels in heart, brain and kidney tissues and reduce MDA content. Conclusion: The antihypertensive effect of Ginkgo biloba extract may be related to the increase of NO content in vasodilative substances, and may play a role in protecting target organs through antioxidation.