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目的评估使用激素补充治疗(HRT)对绝经早期妇女血清生殖激素水平与认知功能的影响。方法对215例围绝经期及绝经后女性进行一般情况、围绝经期症状等调查。从中筛选研究对象共30例,按一般情况、KMI及月经情况等调查结果,组间匹配HRT组(10例),非HRT组(20例),分别测定血清雌激素(E2)、卵泡刺激素(FSH)、雄激素(T)、总胆固醇(TC)及甘油三酯(TC)的水平,并进行认知功能测试评分,分析组间差异。结果 HRT组血清E2水平明显高于非HRT组,FSH水平明显低于非HRT组(P﹤0.05);两组T、TC及TG水平差异无统计学意义(P﹥0.05)。HRT组AVLT、VFT得分明显高于非HRT组,CFT耗时明显低于非HRT组(P﹤0.05),两组MMSE、DST、CFT得分差异无统计学意义(P﹥0.05)。结论HRT可以明显提高绝经早期妇女血清雌激素水平,降低FSH水平;HRT可能提高绝经早期妇女的语言表达能力及短时记忆能力。
Objective To assess the effect of hormone replacement therapy (HRT) on serum reproductive hormone levels and cognitive function in early postmenopausal women. Methods 215 cases of perimenopausal and postmenopausal women for the general situation, perimenopausal symptoms and other investigations. A total of 30 subjects were screened out. According to the general situation, KMI and menstrual status, the results of the investigation were compared between the two groups. HRT group (10 cases) and non-HRT group (20 cases) were used to measure serum estradiol (E2), follicle stimulating hormone (FSH), androgen (T), total cholesterol (TC) and triglyceride (TC) were measured and scores of cognitive function test were analyzed. Results The level of serum E2 in HRT group was significantly higher than that in non-HRT group, and the level of FSH was significantly lower than that of non-HRT group (P <0.05). There was no significant difference in T, TC and TG levels between the two groups (P> 0.05). HRT group AVLT, VFT score was significantly higher than non-HRT group, CFT time was significantly lower than the non-HRT group (P <0.05), MMSE, DST, CFT score was no significant difference between the two groups (P> 0.05). Conclusion HRT can significantly increase the level of serum estrogen and reduce the level of FSH in early postmenopausal women. HRT may improve the language expression and short-term memory of early postmenopausal women.