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目的观察在抗感染的同时采用还原型谷胱甘肽治疗恙虫病合并中毒性肝炎的临床疗效。方法将32例恙虫病合并中毒性肝炎患者随机分为2组,治疗组17例在抗感染及给予甘草酸二铵护肝降酶基础治疗上加用还原型谷胱甘肽,对照组15例仅予抗感染及甘草酸二铵护肝降酶。2组均治疗2周。结果治疗组加用还原型谷胱甘肽可使患者临床症状消失或明显改善,总有效率为88.2%,对照组为66.7%。肝功能各指标恢复正常或下降优于对照组。结论还原型谷胱甘肽治疗恙虫病合并中毒性肝炎疗效良好,安全性高。
Objective To observe the clinical efficacy of reducing glutathione in the treatment of tsutsugamushi disease complicated with toxic hepatitis while anti-infective. Methods Thirty-two cases of tsutsugamushi disease complicated with toxic hepatitis were randomly divided into two groups. In the treatment group, 17 cases were treated with reduced glutathione on the basis of anti-infection and basic treatment of diammonium glycyrrhizinate, and 15 cases in the control group Anti-infective and Glycyrrhizin Liver-Protecting enzyme only. 2 groups were treated for 2 weeks. Results Treatment group with reduced glutathione clinical symptoms disappeared or significantly improved in patients with a total effective rate of 88.2% in the control group was 66.7%. Liver function indicators returned to normal or decline better than the control group. Conclusion Reduced glutathione treatment of tsutsugamushi disease with toxic hepatitis has good curative effect and high safety.