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目的:探讨高同型半胱氨酸水平与脑梗死患者的相关性。方法:选取本院2013年6月-2015年6月收治的957例脑梗死患者作为观察组。对照组为同期的健康体检者900例,取两组患者的晨起空腹静脉血,采用循环酶法对血清同型半胱氨酸的水平进行测定,正常值为5~15μmol/L,>15μmol/L即为高同型半胱氨酸,分析对比测定结果。结果:观察组中有262例高同型半胱氨酸血症,其中男135例,女127例,同型半胱氨酸平均水平为(24.1±2.9)μmol/L,对照组中有137例高同型半胱氨酸血症,其中男95例,女62例,同型半胱氨酸平均水平为(14.7±1.5)μmol/L,组间比较,差异具有统计学意义(P<0.05)。观察组中487例首发脑梗死患者的血浆同型半胱氨酸水平为(19.1±1.5)μmol/L,470例再发脑梗死患者的血浆同型半胱氨酸水平为(25.6±3.0)μmol/L,差异具有统计学意义(P<0.05)。结论:高同型半胱氨酸与脑梗死具有显著相关性,临床治疗时要有效预防患者出现高同型半胱氨酸血症,降低脑梗死发病率和复发率。
Objective: To investigate the correlation between hyperhomocysteine and cerebral infarction. Methods: A total of 957 cerebral infarction patients admitted to our hospital from June 2013 to June 2015 were selected as the observation group. The control group consisted of 900 healthy subjects during the same period. Fasting venous blood samples were taken from the morning of the two groups. The level of serum homocysteine was determined by circulating enzyme method. The normal values were 5-15μmol / L and> 15μmol / L is the high homocysteine, analysis and comparison test results. RESULTS: There were 262 hyperhomocysteinemia patients in the observation group, including 135 males and 127 females, the average level of homocysteine was (24.1 ± 2.9) μmol / L in the observation group and 137 in the control group Homocysteinemia, including 95 males and 62 females, the average level of homocysteine was (14.7 ± 1.5) μmol / L, the difference between the two groups was statistically significant (P <0.05). The level of plasma homocysteine in 487 patients with primary cerebral infarction in the observation group was (19.1 ± 1.5) μmol / L and that of 470 patients with recurrent cerebral infarction was (25.6 ± 3.0) μmol / L, the difference was statistically significant (P <0.05). Conclusion: Homocysteine has a significant correlation with cerebral infarction. The clinical treatment should effectively prevent patients with hyperhomocysteinemia and reduce the incidence and recurrence of cerebral infarction.