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目的分析血清前白蛋白(PA)和胱抑素C(Cys C)水平预示急性有机磷农药中毒(AOPP)患者早期肝肾功能损害的价值。方法检测健康体检者(C组,40例)和AOPP患者(A组,92例)入院24h内肝肾功能相关指标,分析AOPP患者肝肾功能变化与AOPP病情的关系。结果与C组比较,A组患者总蛋白、白蛋白、PA含量稍低,而ALT、AST、血尿素氮(BUN)、血清肌酐(SCr)和Cys C含量稍高(P>0.05)。与C组比较,AOPP重度中毒者血清总蛋白、白蛋白和PA含量降低,BUN、SCr和Cys C水平升高(P<0.05)。结论血清PA降低和Cys C升高预示AOPP,尤其是对重度中毒患者肝肾功能的早期损害有一定价值。
Objective To analyze the value of pre-serum albumin (PA) and cystatin C (Cys C) in predicting the early liver-kidney dysfunction in patients with acute organophosphorus pesticide poisoning (AOPP). Methods The indexes of liver and kidney function in healthy subjects (C group, 40 cases) and AOPP patients (A group, 92 cases) were detected 24h after admission to analyze the relationship between liver and kidney function changes and AOPP in patients with AOPP. Results Compared with group C, the total protein, albumin and PA in group A were slightly lower than those in group C, while the contents of ALT, AST, BUN, SCr and Cys C were slightly higher (P> 0.05). Compared with group C, the levels of serum total protein, albumin and PA, and the levels of BUN, SCr and Cys C in severe AOPP poisoning increased (P <0.05). Conclusions The decrease of serum PA and the increase of Cys C are predictive of AOPP, especially for the early damage of liver and kidney function in patients with severe poisoning.