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1980—87年郑州地区农村痢菌分布与耐药谱监测说明,1980—83年 A 群Ⅰ型痢菌为流行菌型,B 群痢菌多为健康带菌。1983年后,A 群痢菌检出下降,C 群鲍氏痢菌所占比例上升,福氏菌处于相对稳定。药敏监测所示,各型痢菌对红霉素、先锋霉素、四环素、氯霉素、氨苄青霉素和磺胺类均有70.0%以上的耐药,且以多重性耐药为主。每年以1.5%—4.1%的增速率上升。随着用药量的减少(氯霉素)或增多(红霉素),耐药性也呈现下降(氯霉素)或上升(红霉素)。显示用药3—5年可产生耐药性,停用5—10年又可恢复敏感性,同时对预防细菌产生耐药性也提出了一些设想。
From 1980 to 1987, the distribution and the drug resistance spectrum of dysentery in rural areas of Zhengzhou showed that the genotypes Ⅰ and Ⅱ of dysentery were genotype I and d from 1996 to 1983. After 1983, a group of dysentery decreased, the proportion of C group Clostridium dysenteriae increased, fungus in a relatively stable. Drug susceptibility monitoring shows that various types of dysentery bacteria have erythromycin, cephalosporin, tetracycline, chloramphenicol, ampicillin and sulfonamides have more than 70.0% resistance, and multi-drug resistance. Annual growth rate of 1.5% -4.1%. With dose reduction (chloramphenicol) or increased (erythromycin), resistance also showed a decrease (chloramphenicol) or up (erythromycin). Shows 3-5 years of medication can produce drug resistance, 5 to 10 years off and can resume sensitivity, and to prevent bacterial resistance also made some ideas.