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作者用DNA再结合技术从晚期乳腺癌病人身上得到高纯度的人体白细胞A干扰素。用以治疗晚期局限性复发乳腺癌,观察其临床疗效和安全性。发现了干扰素的并发症,即与剂量有关的可逆性中枢神经系统毒性反应,这是过去未曾报道过的。 10例晚期局限性复发乳腺癌妇女曾用放射治疗、激素及化疗无效,用干扰素20×10~6U/m~2每日1次或50×10~6U/m~2每周3次,肌肉注射,共12周。所有病人用药后均出现预期的副作用,包括注射后1小时内发热达40℃,头4天有头痛、肌痛。用扑热息痛1g每日4次有效。未见病人出现急性过敏反应,亦无血压及其它重要脏器的体征变化。用药后第1周出现流感样症状,用脱敏疗法。1周后流感样症状消失,代之以昏睡、恶心、厌食,偶有呕吐。4例由于厌食、恶心,拒食达1周,体重下降10％以上。暂时性白细胞降低及血小板减少,但无须停药。肾功能未受影响,肝功能试验发现有血清转氨酶一过性升高,胆红素浓
The authors use DNA recombination technology to obtain high-purity human leukocyte interferon-alpha from patients with advanced breast cancer. For the treatment of advanced local recurrence of breast cancer, observe its clinical efficacy and safety. Interferon complications have been identified, namely dose-related and reversible CNS toxic reactions, which have not been reported in the past. Ten patients with locally advanced breast cancer with localized recurrence of breast cancer were treated with radiation therapy, hormones and chemotherapy were ineffective, with interferon 20 × 10 ~ 6U / m 2 once daily or 50 × 10 ~ 6U / m ~ 2 three times a week, Intramuscular injection for 12 weeks. All patients showed expected side effects after treatment, including a fever of 40 ° C within 1 hour after injection and headache and myalgia for the first 4 days. Paracetamol 1g 4 times daily effective. No patient had an acute allergic reaction, and no changes in blood pressure and other vital organs. Flu-like symptoms occur on the first week after treatment with desensitization therapy. One week later flu-like symptoms disappear, replaced by lethargy, nausea, anorexia, occasional vomiting. 4 cases due to anorexia, nausea, refuse to eat up to 1 week, weight loss of more than 10%. Temporary leukopenia and thrombocytopenia, but without stopping. Renal function is not affected, liver function tests found that transient increase of serum transaminase, bilirubin