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棉酚作为一种男用节育药被发现以来,人们对其作用原理、药物毒性、药物动力学及其遗传效应进行了大量的研究。结果表明,服用抗生育剂量的棉酚或在较小量棉酚存在的条件下进行细胞培养,都没有引起染色体畸变率的增加。目前,关于棉酚对长期服药个体SCE率影响的研究尚未见报道。为了弄清长期服用抗
Since gossypol was discovered as a male sterility medicine, a great deal of research has been conducted on its action principle, drug toxicity, pharmacokinetics and its genetic effect. The results showed that the use of anti-fertility doses of gossypol or a small amount of gossypol in the presence of cell culture conditions, did not cause an increase in chromosome aberration rates. At present, there is no report on the influence of gossypol on the individual SCE rate in long-term administration. In order to understand the long-term use of anti-