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质谱作为有机药物结构分析的有力工具,已有半个世纪的历史。质谱协同物理化学方法(如,红外、紫外,核磁共振法等)在确定新药的结构式方面已获得广泛应用。由于质谱取样微量(10~(-6)～10~(-9)g)、检出灵敏度高、从微量样品中即可获得大量的数据,因而倍受重视。多年来有机质谱一直沿用电子轰击型离子源,在有机药物结构分析中发挥很大作用,但电子轰击质谱(简称EI)在应用上有局限性,特别是在测定诸如极性强、难气化以及对热不稳定的化合物时,通常不能获得满意的结果。据统计,85%的化合物不能用EI质谱法记录到分子离子峰,为此人们致力于研究“软电离(Soft Ioni-
As a powerful tool for the structural analysis of organic drugs, mass spectrometry has been half a century old. Mass spectrometry synergistic physicochemical methods (such as infrared, ultraviolet, nuclear magnetic resonance, etc.) have been widely used in the determination of the structural aspect of new drugs. Due to the small amount of mass spectrometry (10 ~ (-6) ~ 10 ~ (-9) g), high detection sensitivity, a large amount of data can be obtained from a small amount of sample, so much attention. For many years, organic mass spectrometry has been used electron bombardment ion source, in the analysis of the structure of organic drugs play a great role, but the electron impact mass spectrometry (referred to as EI) has limitations in application, especially in the determination of such as polar, difficult gasification As well as heat-labile compounds, satisfactory results are generally not obtained. According to statistics, 85% of the compounds can not be recorded by EI mass spectrometry molecular ion peak, for which people are committed to studying "Soft Ionization (Soft Ioni-