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目的：研究化学致癌剂的致癌机理和胃癌的发生发展过程。方法：８０只Ｗｉｓｔａｒ大鼠饮用浓度为８０ｍｇ·Ｌ－１的Ｎ－甲基－Ｎ′－硝基－Ｎ－亚硝基胍（Ｎ－ｍｅｔｈｙｌ－Ｎ′－ｎｉｔｒｏ－Ｎ－ｎｉｔｒｏｓｏｇｕａｎｉｄｉｎｅ，ＭＮＮＧ）水溶液９个月，再观察３个月。结果：成功地诱发出胃腺癌、胃腺瘤、胃息肉、胃粘膜不典型增生和肠上皮化生等病变。胃癌肝转移２例，淋巴结转移１例。对大鼠实验性胃癌的发生和发展过程进行了病理形态学研究。结论：胃腺癌组织学类型以分化型腺癌为主，大肠型肠上皮化生和不典型增生是值得高度重视的癌前病变，为研究胃癌发生发展的分子生物学机制提供了一个良好模型。
Objective: To study the carcinogenic mechanism of chemical carcinogens and the occurrence and development of gastric cancer. Methods: 80 Wistar rats were treated with 80 mg·L-1 N-methyl-N′-nitro-N-nitrosoguanidine (MNNG) in aqueous solution. For 9 months, observe for another 3 months. RESULTS: Gastric adenocarcinoma, gastric adenoma, gastric polyps, gastric dysplasia, and intestinal metaplasia were successfully induced. There were 2 cases of liver metastases in gastric cancer and 1 case of lymph node metastasis. The pathomorphological study of the occurrence and development of experimental gastric cancer in rats was performed. Conclusions: The histological type of gastric adenocarcinoma is mainly differentiated adenocarcinoma, and intestinal metaplasia and atypical hyperplasia of the large intestine are valuable precancerous lesions. It provides a good model for studying the molecular biology mechanism of the development of gastric cancer.