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前列腺素是调节机体各种功能的重要生物活性物质。关于前列腺素E_1(PGE_1)有扩张血管、降低血压、抑制血小板聚集,抗组织胺、调节免疫等作用已有报道。但PGE_1能否清除循环免疫复合物国内外尚未见有报导。近来临床应用PGE_1缓解心绞痛与治疗心衰等获得令人鼓舞的效果。我们在应用PGE_1治疗冠心病与心衰过程中发现PGE_1有清除循环免疫复合物(CIC)现象,遂作了进一步的观察,并为研究冠心病的防治提供新的资料。现将其结果报导如下。
Prostaglandins are important bioactive substances that regulate various functions of the body. About prostaglandin E_1 (PGE_1) dilation of blood vessels, lowering blood pressure, inhibiting platelet aggregation, antihistamine, regulate immune function has been reported. However, whether PGE_1 can eliminate circulating immune complexes has not been reported at home and abroad. Recently, the clinical application of PGE 1 to relieve angina and treat heart failure and other encouraging results. In the course of applying PGE_1 to treat coronary heart disease and heart failure, we found that PGE_1 has the phenomenon of clearing the circulating immune complex (CIC), and then made further observations and provided new information for the study of prevention and treatment of coronary heart disease. Now the results reported below.