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目的 :探讨子宫内膜癌宫颈间质浸润的临床病理特征。方法 :回顾性分析2012年1月—2012年12月具备完整病历资料的213例子宫内膜癌患者的临床病理资料,评估子宫内膜癌宫颈间质浸润相关危险因素。结果 :213例子宫内膜癌患者中,宫颈间质浸润71例(33.3%)。单因素分析发现,年龄、体质量指数、空腹血糖、血清总胆固醇、术后病理以及是否合并子宫肌瘤与宫颈间质浸润无明显相关性(P>0.05),而组织学分级、肌层浸润、病变范围以及是否存在脉管癌栓与宫颈间质浸润相关(P<0.05)。多因素分析结果显示,组织学分级和病变范围是子宫内膜癌宫颈间质浸润的独立危险因素。磁共振成像诊断子宫内膜癌宫颈间质浸润的敏感度、特异度和准确性均优于经阴道超声检查。结论 :组织学分级和病变范围是子宫内膜癌宫颈间质浸润的独立危险因素。在预测子宫内膜癌宫颈间质浸润方面,磁共振成像较经阴道超声检查更为可靠。
Objective: To investigate the clinical and pathological features of cervical stromal infiltration in endometrial carcinoma. Methods: The clinical and pathological data of 213 patients with endometrial cancer with complete medical records from January 2012 to December 2012 were retrospectively analyzed to evaluate the risk factors of cervical interstitial infiltration in endometrial cancer. Results: In 213 cases of endometrial cancer, interstitial infiltration in 71 cases (33.3%). Univariate analysis showed that age, body mass index, fasting blood glucose, serum total cholesterol, postoperative pathology and whether or not uterine fibroids with cervical interstitial infiltration had no significant correlation (P> 0.05), while histological grade, myometrial invasion , The extent of the lesion and the existence of vascular tumor thrombus and cervical interstitial infiltration (P <0.05). Multivariate analysis showed that histological grade and extent of lesions were independent risk factors for cervical stromal invasion of endometrial cancer. The sensitivity, specificity and accuracy of magnetic resonance imaging in the diagnosis of cervical stromal infiltration of endometrial carcinoma are superior to transvaginal sonography. Conclusions: Histological grade and lesion extent are independent risk factors of cervical interstitial infiltration in endometrial carcinoma. Magnetic resonance imaging is more reliable than transvaginal ultrasonography in predicting cervical interstitial infiltration in endometrial cancer.