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为揭示应激状态下胃粘膜上皮层抗酸形态屏障及壁细胞超微结构变化，作者采用大鼠水浸束缚方法制作应激模型。检测对照组及应激组胃粘膜损伤指数，并取腺胃区胃粘膜组织制作透射电镜标本，检测粘膜上皮细胞、上皮细胞间连接、上皮下基底膜及壁细胞的超微结构变化。结果发现应激组大鼠较对照组胃粘膜损伤重；电镜观察显示对照组壁细胞多呈静息状态，应激组壁细胞内线粒体丰富，分泌小管密集，呈明显分泌状态；腔面细胞膜损伤，细胞间连接及基底膜无明显破坏。结果提示应激可刺激壁细胞呈分泌状态，胃粘膜上皮层损伤过程中以腔面细胞膜破坏在先，细胞间连接和基底膜在应激性溃疡发生的早期无显著的形态学改变。提示胃粘膜表面上皮层腔面膜的破坏在应激性溃疡的发生过程中具有重要的意义。
To reveal the acid-resistant morphological barrier and the ultrastructure of parietal cells in the gastric mucosa epithelium under stress, the authors used the rat immersion method to make the stress model. The gastric mucosal injury index of the control group and the stress group was detected. The gastric mucosa of the glandular stomach was used to make the transmission electron microscopy. The ultrastructural changes of mucosal epithelial cells, epithelial intercellular junctions, subepithelial basement membrane and parietal cells were detected. The results showed that gastric mucosal injury was heavier in the stress group than in the control group. Electron microscopy showed that most of the parietal cells in the control group were at rest. Mitochondria were abundant in the parietal cells of the stress group. The secretory tubules were dense and secreted. , Cell junctions and basement membrane without obvious damage. The results suggest that stress can stimulate the secretion of parietal cells, the destruction of the gastric mucosal epithelial cell membrane damage in the early cavity, cell junction and basement membrane in the early stage of stress ulcer no significant morphological changes. Prompted the destruction of gastric mucosa epithelial lining of the mask in the process of stress ulcer is of great significance.