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目的:观察鼻内镜手术治疗原发鼻腔鼻窦恶性肿瘤的长期临床疗效,分析手术预后的影响因素。方法:回顾性分析43例鼻内镜下手术治疗的原发性鼻腔鼻窦恶性肿瘤患者的临床诊疗资料。结果:死亡15例,1、2、3、5年生存率分别为83.7%(36/43)、74.4%(32/43)、69.8%(30/43)、65.1%(28/43)。Kaplan-Meier单因素分析结果显示患者性别、肿瘤T分级、TNM分期、病理类型为嗅神经母细胞瘤4个因素对预后的影响有统计学意义(P<0.05);Cox回归模型多因素分析显示TNM分期是影响预后的独立因素。结论:内镜下鼻腔鼻窦恶性肿瘤切除术是一种安全有效的微创外科治疗方法,其可作为传统手术方式的重要补充,患者性别、肿瘤T分级、TNM分期、病理类型为嗅神经母细胞瘤是手术预后的重要影响因素。
Objective: To observe the long-term clinical efficacy of endoscopic sinus surgery in the treatment of primary nasal sinus cancer and analyze the influencing factors of prognosis. Methods: The clinical data of 43 patients with primary nasal sinus cancer treated by endoscopic sinus surgery were analyzed retrospectively. Results: The 15-year survival rate was 83.7% (36/43), 74.4% (32/43), 69.8% (30/43) and 65.1% (28/43) respectively in 15 deaths. The results of Kaplan-Meier univariate analysis showed that there were significant differences in the prognosis between the gender, tumor T grade, TNM stage and pathological type of the olfactory neuroblastoma (P <0.05). Cox regression model multivariate analysis showed TNM staging is an independent factor affecting the prognosis. Conclusion: Endoscopic sinus surgery is a safe and effective minimally invasive surgical treatment, which can be used as an important supplement to traditional surgical methods. Patient’s sex, tumor T grade, TNM stage and pathological type are olfactory neuroblastoma Tumor is an important prognostic factor.