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目的：采用１１１ Ｉｎｐｅｎｔｅｔｒｅｏｔｉｄｅ 生长抑素受体显像（ Ｓ Ｒ Ｓ）对碘扫描阴性的甲状腺滤胞状或乳头状癌患者进行研究，以评价其诊断价值。方法：已行根治术并接受放射性碘治疗的高分化甲状腺癌患者 １６ 例（２３～８４ 岁），其中 １５ 例甲状 腺球蛋白升高被怀疑癌复发，已有 ４ 例证实为肺转移或纵膈病变。１６ 例中的 ５ 例显像前已停用替代治疗，１１ 例正在接受替代治疗。碘显像均呈阴性。所有患者在静脉注射 １３７～２００ Ｍ Ｂｑ １１１ Ｉｎｐｅｎｔｅｔｒｅｏｔｉｄｅ后，分别于 １、４ 和 ２４ 小时用低能高分辨准直器的 γ照相机进行显像。图像判定标准：在 ４ 小时和 ２４ 小时图像上如果怀疑病变处核素摄取和对比随时间呈递增或保持不变，视为阳性；如果是一过性摄取或强度和对比随时间逐渐下降，视为非特异摄取。复发诊断标准：当 Ｃ Ｔ 可疑病变处出现阳性摄取，考虑为真阳性；如 Ｃ Ｔ 未提示的部位出现核素摄取，视为假阳性（经病理证实）。结果：１６ 例中，３ 例 Ｓ Ｒ Ｓ阳性（占 １９％ ），１ 例假阳性（占６％ ），１２ 例假阴性（占７５％ ）。有５ 例只在２４小时图像中出现纵膈或肺部少量核素摄取。 Ｓ Ｒ Ｓ阳性的患者甲状腺球蛋白水平都升?
OBJECTIVE: To evaluate the diagnostic value of iodine-negative thyroid filter-like or papillary carcinoma patients using 111 Inpentetreotide somatostatin receptor imaging (SRS). METHODS: Sixteen patients (23 to 84 years old) with well-differentiated thyroid cancer who had undergone radical thyroidectomy and treated with radioactive iodine, 15 of whom had elevated thyroglobulin were suspected of having cancer recurrence, and 4 have been demonstrated to be pulmonary metastases or mediastinal fistulas. Lesions. Replacement therapy was discontinued before imaging in 5 of the 16 cases, and 11 were undergoing replacement therapy. Iodine imaging was negative. All patients were imaged at 1, 4, and 24 hours using a low-energy high-resolution collimator gamma camera after intravenous injection of 137 to 200 M Bq 111 In-pentetreotide. Image criteria: positive or negative changes in radionuclide uptake and contrast over time on 4 and 24 hour images; if transient uptake or intensity and contrast decline over time, visual For non-specific uptake. Recurrence diagnostic criteria: When positive uptake occurs at C T suspected lesions, consider true positive; if radionuclide uptake occurs at sites not indicated by C T, treat as false positives (pathologically confirmed). Results: Among the 16 cases, 3 were positive for SRS (19%), 1 was false positive (6%), and 12 were false negative (accounting for 75%). In 5 cases, there was only a small amount of nuclide uptake in the mediastinum or lung in the 24-hour image. Patients with SRS positive patients have elevated thyroglobulin levels?