论文部分内容阅读
患者女,38岁。全身红斑、坏死、溃疡伴疼痛发热十月余,加重1个月。皮损表现为小腿部位多发红斑、结节、溃疡及坏死,多次行皮损组织病理检查误诊为“坏疽性脓皮病”。1个月前皮损累及面部,再次行病理活检示:真皮小血管及神经纤维周围伴多量淋巴样细胞浸润,皮下组织并见脂膜炎反应。免疫组化:CD2(+),CD3(+),TIA-1(+),Gr B(+),CD56(+),Ki67[约90%+]及合并EBER(+);TCR无克隆性基因重排。诊断:结外NK/T细胞淋巴瘤(鼻型)。
Female patient, 38 years old. Whole body erythema, necrosis, ulcers with painful fever in October, aggravating a month. Skin lesions showed multiple parts of the lower leg erythema, nodules, ulcers and necrosis, multiple line lesions histological examination misdiagnosed as “gangrenous pyoderma.” 1 month before the skin lesions involving the face, again pathological biopsy showed: dermal small blood vessels and nerve fibers around with large amounts of lymphoid infiltration, subcutaneous tissue and see the reaction of the paniculitis. Immunohistochemistry: CD2 (+), CD3 (+), TIA-1 (+), Gr B (+), CD56 (+), Ki67 [about 90% +] and combined EBER Gene rearrangement. Diagnosis: Extranodal NK / T cell lymphoma (nasal type).