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目的探讨跨膜型黏蛋白1(MUC1)在Ⅰ型子宫内膜癌发生、发展中的作用及其临床意义。方法选择手术切除的增生期子宫内膜组织30份(增生组)、单纯性增生子宫内膜36份(单纯组)、不典型增生内膜组织50份(不典型组)及Ⅰ型子宫内膜癌55份(内膜癌组),采用免疫组化法检测各组MUC1蛋白的表达模式,分析MUC1表达与子宫内膜癌临床病理参数的相关性。结果 MUC1蛋白在增生组和单纯组主要表现为上皮细胞膜顶点和腺体腔源面表达(A模式),在不典型组和内膜癌组表现为整个细胞膜表面或细胞质表达(A/C模式),P均<0.01;内膜癌中MUC1蛋白表达与年龄变化有一定关系(P=0.044),但与组织学分级无关(P=0.678)。结论 MUC1蛋白参与了Ⅰ型子宫内膜癌的发生、发展过程,其在内膜上皮细胞细胞膜表面或细胞质中表达模式可作为诊断子宫内膜癌的参考指标。
Objective To investigate the role of transmembrane-type mucin 1 (MUC1) in the development and progression of type Ⅰ endometrial carcinoma and its clinical significance. Methods Thirty cases of proliferative endometrium (hyperplasia group), 36 hyperplastic endometrium (simple group), 50 atypical hyperplasia endometrium (atypical group) and type Ⅰ endometrium Cancer of 55 cases (endometrial carcinoma group). Immunohistochemistry was used to detect the expression pattern of MUC1 protein in each group. The correlation between MUC1 expression and clinical pathological parameters of endometrial carcinoma was analyzed. Results The expression of MUC1 protein in epithelial cell membrane and glandular cavity surface (A mode) was mainly observed in the proliferative group and simple group. The expression of MUC1 in the atypical and endometrial carcinomas showed the whole cell membrane surface or cytoplasm (A / C mode) , All P <0.01. The expression of MUC1 in endometrial carcinoma was related to age (P = 0.044), but not to the histological grade (P = 0.678). Conclusions MUC1 protein is involved in the development and progression of type Ⅰ endometrial carcinoma. The expression pattern of MUC1 on the membrane surface or in the cytoplasm of endometrial epithelial cells can be used as a reference for diagnosis of endometrial cancer.