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类风湿关节炎(rheumatoid arthritis,RA)的治疗经历了数十年的变革与更新,从70年代末80年代初的“金字塔”模式,过渡到“阶梯式”治疗,直至今日普遍应用的“联合”治疗模式,已使得许多RA患者的病情得到良好的控制。慢作用抗风湿药是一类化学结构不同的免疫调节和免疫抑制剂,有甲氮喋呤、柳氮磺胺吡啶、金制剂、抗疟药(羟氯喹)、硫唑嘌呤、环磷酰胺、环孢素、青霉胺等。由于慢作用抗风湿药种类繁多,如何正确认识并选用它们是临床医生每日都要面对的问题,而有些医生对这类药物的选用随意性及盲目性很大,为了正确地评价它们的作用,合理地选择药物.我们摘译了《Cochrane图书馆)中常用的慢作用抗风湿药治疗RA的随机对照试验(RCTs)和临床对照试验(CCTs)的系统评估文献,以供临床医生参考。
The treatment of rheumatoid arthritis (RA) has undergone decades of transformation and renewal. From the “pyramid” model in the late 1970s to the early 1980s, the treatment of “ladder” "The mode of treatment has led to a good control of the disease in many RA patients. Slow acting antirheumatic drugs are a class of immunomodulatory and immunosuppressive agents with different chemical structures. These include methotrexate, sulfasalazine, gold preparations, antimalarial drugs (hydroxychloroquine), azathioprine, cyclophosphamide, Sporin, penicillamine and so on. Due to the wide variety of slow-acting anti-rheumatic drugs, how to correctly understand and choose them is a problem that clinicians should face daily. Some doctors choose the randomness and blindness of these drugs very much. In order to correctly evaluate them We selected a systematic review of randomized controlled trials (RCTs) and controlled clinical trials (CCTs) of commonly used, slow acting antirheumatic drugs in the RA in the Cochrane Library for reference by clinicians .