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免疫球蛋白重链基因 (IgH)和T细胞受体 (TCR)基因重排常被认为是淋巴细胞的克隆标志。但是 ,近年来的研究表明 ,急性髓性白血病 (AML)细胞亦可出现IgH和TCR基因重排。为此 ,我们采集 5 1例AML患者骨髓 ,利用PCR方法检测IgH及TCRγ基因重排 ,并初步探讨其临床意义。一、资料和方
Immunoglobulin heavy chain gene (IgH) and T cell receptor (TCR) gene rearrangements are often considered as markers of lymphocyte cloning. However, recent studies have shown that IgH and TCR gene rearrangements can also occur in acute myelogenous leukemia (AML) cells. To do this, we collected bone marrow from 51 AML patients and detected the rearrangements of IgH and TCRγ gene using PCR, and discussed its clinical significance. First, the information and party