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目的:探讨乙酰肝素酶、碱性成纤维细胞生长因子的表达与子宫内膜癌浸润、转移及预后的关系。方法:选择2008年3月～2010年10月期间,在该院切除并存档的子宫内膜癌患者子宫内膜石蜡包埋组织标本48例作为研究组,另选同期该院妇产科收治的其他疾病患者,手术切除或刮宫的子宫内膜标本34例作为比较组,及正常子宫内膜21例作为对照组,分别比较分析Hpa和bFGF的染色强度及表达阳性率。结果:与FIGOⅠ期相比,Ⅱ期和Ⅲ期患者Hpa和bFGF的阳性率明显提高;与G1分化相比,G2分化患者Hpa和bFGF的阳性率明显提高;与无肌层浸润相比,肌层浸润浅部和深部患者Hpa和bFGF的阳性率明显提高,差异均具有统计学意义(P<0.05);与对照组患者相比,比较组患者和研究组患者的Hpa和bFGF阳性率均明显提高,差异均具有统计学意义(P<0.05),且研究组的阳性率高于比较组。结论:乙酰肝素酶和碱性成纤维细胞生长因子的表达与子宫内膜癌浸润、转移、预后密切相关,并且有望成为子宫内膜癌联合诊断和病情评估以及疗效观察和预后预测的重要检测指标,同时也可能为子宫内膜癌的治疗提供一种更为有效的解决方案。
Objective: To investigate the relationship between the expression of heparanase, basic fibroblast growth factor and the infiltration, metastasis and prognosis of endometrial carcinoma. Methods: From March 2008 to October 2010, 48 cases of endometrial paraffin-embedded tissue specimens from patients with endometrial cancer who were excised and filed in the hospital were selected as the study group, while the other obstetrics and gynecology patients Other diseases, 34 cases of resection or curettage of endometrium as control group and 21 cases of normal endometrium as control group were compared and analyzed respectively Hpa and bFGF staining intensity and positive expression rate. Results: The positive rates of Hpa and bFGF in patients with stage Ⅱ and Ⅲ were significantly higher than those in FIGO stage Ⅰ. The positive rates of Hpa and bFGF in patients with G2 differentiation were significantly higher than those in patients with FIGO stageⅠ. Compared with those without myometrial invasion, The positive rates of Hpa and bFGF in superficial and deep infiltrating patients were significantly higher than those in control group (P <0.05). The positive rates of Hpa and bFGF in patients in comparison group and study group were significantly higher than those in control group Improve, the differences were statistically significant (P <0.05), and the positive rate of the study group was higher than the comparison group. CONCLUSION: The expression of heparanase and basic fibroblast growth factor are closely related to the invasion, metastasis and prognosis of endometrial carcinoma, and are expected to be the important diagnostic and prognostic indicators for endometrial carcinoma combined with the observation of therapeutic effect and prognosis Indicators, but also may provide a more effective solution for the treatment of endometrial cancer.